Question Everything

Why Were The Native Americans Unable to Sucessfully Defend Themselves from European Aggression?
Disease probably played a greater role than anything in killing the natives off. Plus they were far too trusting of the Europeans. If, instead of often attempting to maintain friendly relations, they formed a broad coalition against the Europeans and eliminated every European who left his hemisphere they may have been able to repell the invaders even without the European's technology of death.

Europeans didn't come to the "New World" to escape tyranny, they came here to conquer. There were some revolutionary movements and some had similarities to anarchism at that time period, but none called themselves anarchists because this predated anarchism in the modern sense. See The Many-Headed Hydra: The Hidden History Of The Revolutionary Atlantic by Peter Linebaugh & Marcus Rediker.